Description

Deoxy-(Thymidylyl-Adenylyl-Adenylyl-Thymidylic Acid) is a defined-sequence oligonucleotide, specifically a tetramer composed of deoxythymidine and deoxyadenosine nucleotides. This compound is a critical building block and research tool in molecular biology and genetic engineering. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical developers engaged in nucleic acid synthesis, primer design, and probe development. Its defined sequence allows for precise hybridization studies and serves as a model system for understanding DNA structure and interactions.

Application

• Oligonucleotide Synthesis Building Block: Used as a phosphoramidite or solid-support precursor for the automated synthesis of longer DNA strands.
• Primer and Probe Development: Serves as a core sequence or model for designing PCR primers, sequencing primers, and hybridization probes for diagnostic assays.
• Biochemical Research: Employed in studies of DNA-protein interactions, enzyme kinetics (e.g., with polymerases or nucleases), and nucleic acid structure.
• Quality Control Standard: Acts as a reference standard in analytical methods like HPLC or Mass Spectrometry to validate the synthesis and purity of oligonucleotides.
• Antisense & Aptamer Research: Provides a short, defined sequence for initial screening and development of antisense oligonucleotides or DNA aptamers.

Basic Information

Product Name	Deoxy-(Thymidylyl-Adenylyl-Adenylyl-Thymidylic Acid)
CAS No.	80460-62-4
Molecular Formula	C39H49N15O22P3
Molecular Weight	1188.82 g/mol
Synonyms	d(TpApApT); T-A-A-T Tetramer; Thymidylyl-(3'→5')-adenylyl-(3'→5')-adenylyl-(3'→5')-thymidine 5'-triphosphate; Deoxythymidylyl-deoxyadenylyl-deoxyadenylyl-deoxythymidylic Acid; Oligonucleotide d(TAAT); DNA Tetramer TAAT; 5'-d(TAAT)-3'; Deoxyribooligonucleotide TAAT
EINECS	Contact for details

Quality Control

Our oligonucleotides are produced and analyzed under stringent quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to ISO 9001 quality management principles, and our analytical methods are validated to meet the exacting standards required for life science research.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 85% (on dried basis)
Water Content (KF)	≤ 5.0%
Extinction Coefficient (ε260)	Contact for details
Molecular Weight (MS)	1188.82 ± 2 Da

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.