Description

4-Chlorobenzylmagnesium Chloride is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the formation of carbon-carbon bonds. Its primary value lies in its ability to introduce the 4-chlorobenzyl group into target molecules, enabling the construction of complex intermediates for advanced materials and pharmaceuticals. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for the production of active pharmaceutical ingredients (APIs), particularly in the synthesis of compounds with chlorobenzyl moieties.
• Agrochemical Manufacturing: Used in the creation of advanced herbicides, fungicides, and insecticides where the 4-chlorobenzyl group imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials by incorporating functional aromatic groups.
• Fine Chemical Production: Facilitates the synthesis of complex fragrance and flavor ingredients, as well as dyes and pigments.
• Academic & Industrial R&D: A fundamental reagent in research laboratories for methodological development and exploring new synthetic pathways.

Basic Information

Product Name	4-Chlorobenzylmagnesium Chloride
CAS No.	874-72-6
Molecular Formula	C7H6ClMgCl (often represented as 4-ClC6H4CH2MgCl)
Molecular Weight	189.38 g/mol (as chloride salt)
Synonyms	(4-Chlorophenyl)methylmagnesium Chloride; p-Chlorobenzylmagnesium Chloride; 1-(Chloromethyl)-4-chlorobenzene, Magnesium derivative; Grignard Reagent, 4-Chlorobenzylmagnesium Chloride; 4-Chlorobenzylmagnesium Chloride solution; Magnesium, chloromethyl-4-chlorophenyl-; 4-Cl-BnMgCl
EINECS	Contact for details

Quality Control

Our 4-Chlorobenzylmagnesium Chloride is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing to ensure consistency, purity, and reactivity. We provide comprehensive Certificates of Analysis (COA) detailing concentration (typically in standard solvents like THF or diethyl ether), assay by titration, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical applications and ISO standards for industrial use.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile and hygroscopic (moisture-sensitive). For optimal stability and safety, store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for extended periods. Keep away from heat, sparks, open flames, and incompatible materials such as strong acids, water, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear solution, colorless to light brown
Concentration	0.5 M to 2.0 M in specified solvent (e.g., THF)
Assay (Titration)	≥ 95% (as Grignard reagent)
Identification (IR)	Conforms to structure
Solvent (Typical)	Tetrahydrofuran (THF) or Diethyl Ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.