Description

m-Peg8-Nhs Ester CAS NO 756525-90-3 is a heterobifunctional polyethylene glycol (PEG) linker featuring an amine-reactive N-hydroxysuccinimide (NHS) ester at one terminus. This compound is essential for creating stable amide bonds between PEG chains and primary amines, a fundamental reaction in bioconjugation and surface modification. It is a critical reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries who require reliable, high-purity linkers for developing advanced therapeutics and biomaterials.

Application

• Bioconjugation and Protein PEGylation: Covalently attaching PEG chains to therapeutic proteins, peptides, and antibodies to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Nanoparticle and Liposome Functionalization: Surface modification of drug delivery carriers to improve biocompatibility, stability, and targeted delivery capabilities.
• Crosslinking and Immobilization: Creating stable linkages for immobilizing biomolecules onto solid supports for biosensors, diagnostic assays, and affinity chromatography resins.
• Synthesis of ADC Linkers: Serving as a key intermediate in the construction of cleavable or non-cleavable linkers for Antibody-Drug Conjugates (ADCs).
• Hydrogel and Biomaterial Synthesis: Crosslinking agent for creating PEG-based hydrogels and scaffolds used in tissue engineering and controlled drug release systems.
• Surface Coatings: Modifying material surfaces (e.g., glass, metals, polymers) with a hydrophilic PEG layer to create anti-fouling or non-adhesive coatings.

Basic Information

Product Name	m-Peg8-Nhs Ester
CAS No.	756525-90-3
Molecular Formula	C25H43NO13
Molecular Weight	565.61 g/mol
Synonyms	8-Azido-3,6,9,12,15,18,21,24-octaoxapentacosanoic acid 2,5-dioxo-1-pyrrolidinyl ester; α-Methoxy-ω-NHS ester PEG8; mPEG8-NHS ester; Methoxy-PEG8-NHS ester; NHS-PEG8-OMe; N-(Methoxy PEG8) succinimidyl ester; 2,5-Dioxopyrrolidin-1-yl 8-methoxy-3,6,9,12,15,18,21,24-octaoxaoctacosanoate
EINECS	Contact for details

Quality Control

Our m-Peg8-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.