Description

Dna, D(p-Thio) (G-A-T-C-C-G-C-G-G-G-A-A-A-T), Tridecasodium Salt is a chemically modified oligonucleotide sequence where specific phosphate groups are replaced with phosphorothioate (p-Thio) linkages, enhancing its nuclease resistance and stability. This modification is critical for applications requiring prolonged biological activity and structural integrity in complex environments. It is an essential research-grade biochemical for molecular biology, diagnostics, and therapeutic development, particularly in antisense technology and high-fidelity hybridization studies.

Application

• Antisense Oligonucleotide (ASO) Research: Serves as a stable, nuclease-resistant probe for gene silencing and functional genomics studies.
• Diagnostic Probe Development: Used in the design of sensitive and specific hybridization probes for PCR, microarrays, and fluorescence in situ hybridization (FISH).
• Therapeutic Candidate Screening: A key intermediate in the development and evaluation of phosphorothioate-based therapeutic oligonucleotides.
• Biophysical & Structural Studies: Employed to investigate nucleic acid-protein interactions, duplex stability, and the effects of backbone modifications.
• Sensor and Aptamer Construction: Provides a robust scaffold for creating biosensors and aptamers due to its enhanced chemical stability.
• Quality Control Reference Standard: Acts as a characterized standard for the analysis and quality control of other oligonucleotide syntheses.

Basic Information

Product Name	Dna, D(p-Thio) (G-A-T-C-C-G-C-G-G-G-A-A-A-T), Tridecasodium Salt
CAS No.	744239-10-9
Molecular Formula	C130H151N52Na13O71P13S13
Molecular Weight	Contact for details
Synonyms	Phosphorothioate Oligodeoxyribonucleotide (Sequence: 5'-G-A-T-C-C-G-C-G-G-G-A-A-A-T-3'); PS-ODN (GATCCGCGGGAAAT); DNA, d(p-thio)[d(GATCCGCGGGAAAT)], tridecasodium salt; Thiophosphate-modified DNA tridecamer; Antisense Oligonucleotide Sequence GATCCGCGGGAAAT; 13-mer Phosphorothioate DNA Oligo; S-Oligonucleotide (GATCCGCGGGAAAT)
EINECS	Contact for details

Quality Control

Every batch of our oligonucleotides is synthesized and purified under stringent, GMP-like conditions to ensure the highest consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity, Mass Spectrometry (MS) for identity confirmation, and UV spectroscopy for quantification. A detailed Certificate of Analysis (COA) documenting identity, purity, concentration, and endotoxin levels is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake. Aliquot into single-use volumes to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 85% (by weight)
Sequence Verification (MS/MS)	Conforms to specified sequence
Endotoxin Level	< 10 EU/mg
Solubility	Soluble in water, TE buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.