Description

3-Quinolylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, with the CAS number 738580-61-5. It is a critical building block in organic synthesis, enabling the efficient formation of carbon-carbon bonds to introduce the versatile quinoline scaffold into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing quinoline-based active pharmaceutical ingredients (APIs) and drug candidates with potential biological activity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that incorporate the quinoline moiety for enhanced efficacy.
• Material Science Precursor: Serves as a building block for creating organic ligands, functionalized polymers, and electronic materials with specific quinoline functionalities.
• Cross-Coupling Reactions: Employed in transition-metal catalyzed reactions, such as Kumada coupling, to construct biaryl and complex molecular architectures.
• Nucleophilic Addition: Reacts with a wide range of electrophiles including carbonyl compounds (aldehydes, ketones, esters) and epoxides to form new C-C bonds.
• Fine Chemical Production: Integral to the custom synthesis of specialty chemicals, dyes, and photoinitiators requiring the quinoline structure.

Basic Information

Product Name	3-Quinolylmagnesium Bromide
CAS No.	738580-61-5
Molecular Formula	C9H6BrMgN
Molecular Weight	232.36 g/mol
Synonyms	Magnesium, bromo(3-quinolyl)-; 3-Quinolinylmagnesium bromide; Quinolin-3-ylmagnesium bromide; 3-Quinolyl Grignard Reagent; 3-Quinolylmagnesium Bromide Solution; 3-BMgQuinoline; (Quinolin-3-yl)magnesium bromide
EINECS	Contact for details

Quality Control

Our 3-Quinolylmagnesium Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is analyzed to confirm identity, purity, and concentration (typically supplied as a solution in THF or diethyl ether). A comprehensive Certificate of Analysis (COA) detailing assay (by titration), residual solvent content, and other critical parameters is provided with every shipment to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive and moisture-sensitive nature, this material must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions to maintain stability and prevent decomposition. The storage area must be dry, well-ventilated, and free from sources of ignition.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Identification (IR)	Conforms
Assay (Titration)	0.5 M in THF (or as specified)
Purity (HPLC)	≥ 95% (of active reagent)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.