Description

2-Ethoxybenzylmagnesium Chloride is a highly reactive Grignard reagent, an organomagnesium compound essential for forming new carbon-carbon bonds in complex organic synthesis. Its value lies in its ability to introduce the 2-ethoxybenzyl moiety, a versatile building block for constructing advanced molecular architectures. This reagent is critical for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to synthesize novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing active pharmaceutical ingredients (APIs), particularly those containing substituted benzyl or phenethylamine structures.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators that require the ethoxybenzyl functional group.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized phosphine or nitrogen-based ligands used in asymmetric catalysis.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers with tailored properties.
• Fine Chemical Manufacturing: Facilitates the production of specialty flavors, fragrances, and dyes through precise benzylation reactions.
• Academic & Industrial R&D: A fundamental tool for methodological development and exploratory synthesis in organic chemistry laboratories worldwide.

Basic Information

Product Name	2-Ethoxybenzylmagnesium Chloride
CAS No.	738580-60-4
Molecular Formula	C9H11ClMgO
Molecular Weight	194.94 g/mol
Synonyms	(2-Ethoxyphenyl)methylmagnesium Chloride; 2-Ethoxybenzylmagnesium Chloride solution; o-Ethoxybenzylmagnesium Chloride; Magnesium, chlorido(2-ethoxybenzyl)-; (2-Ethoxybenzyl)magnesium Chloride; Grignard Reagent (2-Ethoxybenzyl-MgCl); 1-(Chloromagnesio)methyl-2-ethoxybenzene
EINECS	Contact for details

Quality Control

Our 2-Ethoxybenzylmagnesium Chloride is produced under stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthetic steps. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing concentration, purity, and reactivity. We adhere to cGMP principles where applicable, and our quality systems are designed to support the demanding requirements of pharmaceutical and advanced material synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions to maintain stability and prevent decomposition. Due to its hygroscopic and moisture-sensitive nature, all handling must be performed under anhydrous conditions using standard Schlenk or glovebox techniques.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom)
Assay (Titration)	≥ 95.0%
Identification (IR / NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.