Description

3,4-Difluorobenzylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its value lies in its ability to introduce the versatile 3,4-difluorobenzyl group into molecular frameworks, a key structural motif for modulating the physical and biological properties of target compounds. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, where the difluorobenzyl group is a common pharmacophore.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where fluorinated aromatic rings enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a key reagent in the synthesis of fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Employed in Kumada and other transition metal-catalyzed cross-coupling reactions to create complex biaryl and other aromatic structures.
• Nucleophilic Addition: Reacts with a wide range of electrophiles including carbonyl compounds (aldehydes, ketones, esters), epoxides, and nitriles to form new alcohols, extended carbon chains, and other functional groups.
• Custom & Contract Manufacturing: An essential tool for fine chemical and custom synthesis organizations producing bespoke molecules for client research and development programs.

Basic Information

Item	Detail
Product Name	3,4-Difluorobenzylmagnesium Bromide
CAS No.	738580-43-3
Molecular Formula	C7H5BrF2Mg
Molecular Weight	223.32 g/mol
Synonyms	(3,4-Difluorophenyl)methylmagnesium Bromide; 3,4-Difluorobenzylmagnesium Bromide Solution; Magnesium, bromo[(3,4-difluorophenyl)methyl]-; Grignard Reagent (3,4-Difluorobenzyl); 3,4-Difluorobenzyl Magnesium Bromide; (3,4-Difluorobenzyl)magnesium Bromide; 3,4-DFB-MgBr
EINECS	Contact for details

Quality Control

Our 3,4-Difluorobenzylmagnesium Bromide is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent content, to ensure consistency and reliability for your sensitive synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with internal quality standards and regulatory documentation needs.

Storage

Preserve in a tightly closed container under an inert atmosphere (argon or nitrogen), protected from light, and stored in a cool, dry, well-ventilated place. Due to its highly volatile and pyrophoric nature in solution, it must be handled and stored under strictly anhydrous and oxygen-free conditions. Recommended storage temperature is as specified on the container label, typically between 2°C and 8°C for extended stability.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (of stated concentration)
Purity (GC/HPLC)	Contact for details
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.