Description

4-Isoquinolinmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, used in advanced organic synthesis. Its core value lies in its ability to act as a powerful nucleophile for the efficient formation of carbon-carbon bonds, enabling the construction of complex isoquinoline-based molecular frameworks. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and scalable synthetic methodologies.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the preparation of active pharmaceutical ingredients (APIs) containing the isoquinoline pharmacophore, used in treatments for various diseases.
• Agrochemical Development: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require specific isoquinoline structures for enhanced activity.
• Ligand and Catalyst Preparation: Serves as a precursor for the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and conductive polymers, where the isoquinoline unit modifies electronic properties.
• Academic and R&D Laboratories: A critical reagent for methodological development and the exploration of new reaction pathways in synthetic organic chemistry.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.

Basic Information

Product Name	4-Isoquinolinmagnesium Bromide
CAS No.	738580-40-0
Molecular Formula	C9H6BrMgN
Molecular Weight	232.36 g/mol
Synonyms	4-Isoquinolylmagnesium Bromide; Magnesium, bromo(4-isoquinolinyl)-; 4-Isoquinoline Grignard Reagent; 4-Isoquinolinylmagnesium Bromide; Bromo(4-isoquinolinyl)magnesium; 4-Isoquinoline, bromomagnesium deriv.; 4-Isoquinolinemagnesium Bromide Solution; (4-Isoquinolinyl)magnesium Bromide
EINECS	Contact for details

Quality Control

Our 4-Isoquinolinmagnesium Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and solution concentration, typically provided as a standardized solution in tetrahydrofuran (THF) or diethyl ether. A comprehensive Certificate of Analysis (COA) detailing assay (by titration), residual solvent content, and other critical parameters is available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) to prevent decomposition. For optimal stability, store at 2-8°C. The container should be kept in a cool, dry, well-ventilated area, away from incompatible materials such as strong acids, oxidizers, and water sources.

Specification

Item	Specification
Appearance (Solution)	Colorless to light yellow or brown solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (HPLC)	≥ 95% (of active reagent)
Water Content (KF)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.