Description

5,12-Naphthacenedione, 10-((3-Amino-2,3,6-Trideoxy-α-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-8-(2-Oxopropyl)-, (8S-Cis)- is a complex, high-purity anthracycline derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a critical chemical reference standard and a potential key intermediate for the synthesis of novel therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors working on next-generation oncology treatments and specialized chemical libraries.

Application

• Pharmaceutical Reference Standard: Serves as a certified analytical standard for quality control and method validation in the production of anthracycline-based APIs.
• Anticancer Drug Research: Acts as a sophisticated building block or a lead compound for the synthesis and structure-activity relationship (SAR) studies of novel chemotherapeutic agents.
• Biochemical Research: Used in studies investigating mechanisms of action, such as DNA intercalation and topoisomerase II inhibition, relevant to cancer biology.
• Process Chemistry Development: Employed as a high-value intermediate in the development and scale-up of complex multi-step synthetic routes for specialty pharmaceuticals.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in medicinal chemistry and organic synthesis.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services for client-specific drug discovery programs.

Basic Information

Item	Details
Product Name	5,12-Naphthacenedione, 10-((3-Amino-2,3,6-Trideoxy-α-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-8-(2-Oxopropyl)-, (8S-Cis)-
CAS No.	79438-97-4
Molecular Formula	C26H31NO11
Molecular Weight	533.53 g/mol
Synonyms	10-((3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-8-(2-oxopropyl)-5,12-naphthacenedione; 4-Demethoxy-11-deoxy-13-deoxo-13-oxodaunorubicin; 4-DM-11-deoxy-13-oxo-DNR; 13-Oxodaunorubicin derivative; Anthracycline glycoside intermediate; (8S-cis)-Isomer of the specified naphthacenedione glycoside. Contact for additional aliases.
EINECS	Contact for details

Quality Control

Every batch of this high-purity compound is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles to ensure it meets the exacting standards required for research and development. Our quality commitment aligns with cGMP principles where applicable, and specifications can be tailored to support regulatory filings (e.g., ICH Q3A/B, USP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 0.5 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.