Description

Maytansine, 2-De(Acetylmethylamino)-15-Hydroxy-2-Methyl-, (15S)- is a highly potent cytotoxic ansamycin derivative, serving as a critical intermediate and payload in the development of antibody-drug conjugates (ADCs). Its primary value lies in enabling targeted cancer therapies that aim to deliver potent cytotoxic effects directly to tumor cells while minimizing systemic toxicity. This compound is essential for pharmaceutical R&D teams, process chemists, and manufacturers focused on next-generation oncology therapeutics, particularly in the ADC and targeted drug delivery space.

Application

• Antibody-Drug Conjugate (ADC) Payload: A key cytotoxic warhead for constructing targeted cancer therapies.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies of novel anti-cancer agents.
• Process Chemistry: Serves as a crucial intermediate for the synthesis of more complex maytansinoid derivatives and linker-payload constructs.
• Bioconjugation Studies: Employed in the development and optimization of chemical linker technologies for stable attachment to monoclonal antibodies.
• Mechanistic Studies: Used to investigate microtubule inhibition and the mechanisms of action of maytansinoids in cell biology.
• Potency Standard: Acts as a benchmark for calibrating bioassays and evaluating the cytotoxicity of new therapeutic candidates.

Basic Information

Product Name	Maytansine, 2-De(Acetylmethylamino)-15-Hydroxy-2-Methyl-, (15S)-
CAS No.	79082-27-2
Molecular Formula	C34H46ClN3O9
Molecular Weight	676.20 g/mol
Synonyms	DM1; Mertansine; Ansamitocin P-3'; (15S)-15-Hydroxy-2'-de(acetylmethylamino)-2'-methylmaytansine; NSC-330507; Maytansinoid DM1; N2-Deacetyl-N2-(3-mercapto-1-oxopropyl)-maytansine; Immunogen mAb-maytansinoid conjugate payload
EINECS	Contact for details

Quality Control

Our Maytansine, 2-De(Acetylmethylamino)-15-Hydroxy-2-Methyl-, (15S)- is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets exacting standards for use in critical bioconjugation and formulation work. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Store in a dedicated, secure area for potent compounds.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.