Description

13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxy-N1-[3-(Morpholino)Propyl]Bleomycinamide CAS NO 77368-76-4 is a structurally complex, semi-synthetic derivative of the bleomycin family of glycopeptide antibiotics. This compound is of significant interest for its potential as a high-purity research chemical and as a key intermediate in the development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on oncology drug discovery and advanced molecular synthesis.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate or reference standard in the synthesis and study of next-generation bleomycin analogs for cancer therapy.
• Oncology Drug Discovery: Used in biochemical and cellular assays to investigate structure-activity relationships (SAR) and mechanisms of action targeting DNA cleavage.
• Academic & Clinical Research: Employed as a tool compound for studying the pharmacology, resistance mechanisms, and potential side effects of glycopeptide antibiotics.
• Fine Chemical Synthesis: Acts as a sophisticated building block for the custom synthesis of specialized chemical entities for targeted therapeutic applications.
• Bioconjugation Studies: The functional groups present make it suitable for conjugation studies aimed at developing antibody-drug conjugates (ADCs) or other targeted delivery systems.
• Quality Control & Analytical Standards: Used as a certified reference material (CRM) or high-purity standard for HPLC, LC-MS, or NMR analysis in quality assurance laboratories.

Basic Information

Item	Details
Product Name	13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxy-N1-[3-(Morpholino)Propyl]Bleomycinamide
CAS No.	77368-76-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bleomycinamide, 13-[(4-amino-4,6-dideoxy-α-L-talopyranosyl)oxy]-19-demethyl-12-hydroxy-N1-[3-(4-morpholinyl)propyl]-; 19-Demethyl-12-hydroxybleomycinamide derivative; N1-[3-(Morpholino)propyl]bleomycinamide; Talopyranosyloxy bleomycin analog; Bleomycin A2 derivative; BLM derivative; GP-1 derivative
EINECS	Contact for details

Quality Control

Our production of 13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxy-N1-[3-(Morpholino)Propyl]Bleomycinamide adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided, documenting batch-specific data to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.