Description

Insulin Chain A, Oxidized Ammonium Salt is a high-purity synthetic peptide fragment derived from the A-chain of insulin, specifically in its oxidized (disulfide-bonded) form. This compound is a critical reference standard and intermediate in pharmaceutical research and development, particularly for studies involving insulin structure, function, and quality control. It is essential for researchers and manufacturers in the biopharmaceutical, diagnostic, and academic sectors who require precise molecular tools for analytical method development, metabolic studies, and the production of insulin-based therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of insulin and its analogs in compliance with pharmacopeial monographs (USP, EP).
• Biochemical Research: Serves as a key intermediate in studies of insulin's three-dimensional structure, folding mechanisms, and disulfide bond formation.
• Analytical Method Development: Critical for calibrating and validating analytical techniques such as High-Performance Liquid Chromatography (HPLC), Mass Spectrometry (MS), and Capillary Electrophoresis (CE) in quality control laboratories.
• Diagnostic Reagent Production: Employed in the development and manufacturing of immunoassays and biosensors for the detection of insulin and related metabolic markers.
• Peptide Synthesis & Conjugation: Acts as a building block for the chemical synthesis of novel insulin derivatives or for conjugation in drug delivery system research.

Basic Information

Product Name	Insulin Chain A, Oxidized Ammonium Salt
CAS No.	77282-71-4
Molecular Formula	C254H377N65O75S6 • xNH3
Molecular Weight	~5800 g/mol (Free acid, average)
Synonyms	Insulin A Chain (Oxidized) Ammonium Salt; A-Chain of Insulin (Oxidized); Insulin A-Chain, Disulfide Form; Oxidized Insulin A-Chain; Insulin Chain A (S-S); Gly-Ile-Val-Glu-Gln-Cys-Cys-Ala-Ser-Val-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn (Disulfide bonds: 6-11, 7-20); Insulin A-Chain Peptide
EINECS	Contact for details

Quality Control

Our Insulin Chain A, Oxidized Ammonium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. Certificates of Analysis (COA) are provided, detailing results from tests including HPLC purity, MS confirmation, amino acid analysis, and endotoxin levels where specified.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Ammonium Salt Content	Confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.