Description

Pth-Dl-Histidine is a protected derivative of the essential amino acid histidine, where the amine group is shielded by a phthaloyl (Pth) protecting group. This modification is crucial in peptide synthesis and organic chemistry, preventing unwanted side reactions and enabling the selective construction of complex molecules. It serves as a key chiral building block and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors.

Application

• Peptide Synthesis: A critical intermediate for the solid-phase and solution-phase synthesis of peptides and proteins, where the Pth group protects the α-amino functionality.
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing histidine or imidazole motifs.
• Biochemical Research: Employed in studies of enzyme mechanisms, protein structure-function relationships, and as a precursor for labeled compounds.
• Chiral Resolution Studies: The DL (racemic) form is useful in method development for separating enantiomers and studying stereoselective processes.
• Organic Synthesis: Serves as a versatile building block for constructing more complex heterocyclic compounds and fine chemicals.

Basic Information

Product Name	Pth-Dl-Histidine
CAS No.	66428-49-7
Molecular Formula	C14H13N3O4
Molecular Weight	287.27 g/mol
Synonyms	N-Phthaloyl-DL-histidine; DL-Histidine N-phthaloyl derivative; Phthalimidohistidine; 2-(3H-Imidazol-4-yl)-N-(1,3-dioxoisoindolin-2-yl)propanoic acid; N-Pth-DL-His-OH; PTH-DL-His; (RS)-2-(1,3-Dioxoisoindolin-2-yl)-3-(1H-imidazol-5-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Pth-Dl-Histidine is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	± 0.5° (c=1 in suitable solvent)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.