Description

Phenylthiohydantoin Asparagine is a specialized derivative of asparagine, a key amino acid, modified with a phenylthiohydantoin moiety. This compound is of significant value in advanced biochemical research and analytical chemistry, particularly in peptide and protein sequencing methodologies. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and diagnostic manufacturers engaged in proteomics and amino acid analysis.

Application

• Edman Degradation Reagent: Acts as a critical intermediate or reference standard in the stepwise degradation of peptides for N-terminal amino acid sequencing.
• Analytical Reference Standard: Used for the calibration of HPLC, LC-MS, and other chromatographic systems in proteomic research.
• Biochemical Research: Serves as a building block or model compound in studies of amino acid chemistry, protein structure, and post-translational modifications.
• Pharmaceutical Development: Employed in the synthesis and quality control of peptide-based active pharmaceutical ingredients (APIs) and therapeutic agents.
• Diagnostic Kit Manufacturing: Incorporated as a key component in diagnostic assays and kits designed for amino acid or protein analysis.

Basic Information

Product Name	Phenylthiohydantoin Asparagine
CAS No.	29588-03-2
Molecular Formula	C₁₃H₁₅N₃O₃S
Molecular Weight	293.34 g/mol
Synonyms	PTH-Asparagine; 3-[(Phenylamino)(thioxo)methyl]-2,5-dioxo-4-imidazolidinepropanoic Acid; PTH-Asn; Asparagine Phenylthiohydantoin; N-Phenylthiocarbamoyl-Asparagine; Edman Degradation Product of Asparagine; 2-[(4-Hydroxy-2,5-dioxo-1-imidazolidinyl)carbonylamino]-3-phenyl-2-propenethioamide (related form); Fmoc-Asn(PTH)-OH (protected form derivative)
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin Asparagine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.