Description

Pth-Dl-Citrulline is a protected derivative of the amino acid citrulline, specifically featuring a phthaloyl (Pth) protecting group on the amino functionality. This compound is a critical building block in advanced organic synthesis, particularly in peptide chemistry, where it enables the controlled and selective formation of peptide bonds. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis: Serves as a key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS) to prevent unwanted side reactions.
• Pharmaceutical Research: Used in the research and development of peptide-based therapeutics and drug candidates targeting various diseases.
• Biochemical Studies: Employed as a reagent in enzymatic studies and for probing protein structure-function relationships.
• Fine Chemical Production: Acts as a precursor for the synthesis of more complex, non-proteinogenic amino acids and specialized chiral compounds.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	Pth-Dl-Citrulline
CAS No.	66428-48-6
Molecular Formula	C₁₄H₁₆N₄O₅
Molecular Weight	320.30 g/mol
Synonyms	Nα-Phthaloyl-DL-citrulline; DL-2-Amino-5-ureidopentanoic acid N-phthalimide; N-Phthaloyl-DL-citrulline; Phthalimido-DL-citrulline; Nα-Phthaloyl-DL-citrulline; PTH-DL-Citrulline; N-(1,3-Dioxoisoindolin-2-yl)-DL-citrulline; 2-[(5-Ureidopentanoyl)amino]isoindoline-1,3-dione
EINECS	Contact for details

Quality Control

Our Pth-Dl-Citrulline is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-mixture (Racemic)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.