Description

Pth-L-Histidine Hydrochloride is a protected derivative of the essential amino acid L-Histidine, where the amine group is blocked by a phthaloyl (Pth) protecting group. This modification is critical for enabling selective peptide synthesis and advanced biochemical research where specific functional group manipulation is required. It serves as a key chiral building block and intermediate for pharmaceutical R&D, particularly in the development of peptide-based therapeutics, diagnostic agents, and high-value fine chemicals.

Application

• Peptide Synthesis Intermediate: A crucial protected amino acid for solid-phase and solution-phase peptide synthesis (SPPS), preventing unwanted side reactions at the histidine side chain.
• Pharmaceutical Research & Development: Used as a chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially peptide hormones and enzyme inhibitors.
• Biochemical Reagent: Employed in enzymatic studies and as a standard or reference material in analytical laboratories for method development and validation.
• Fine Chemical Production: Acts as a specialized intermediate in the multi-step synthesis of complex organic molecules and custom compounds for the life sciences industry.
• Protecting Group Chemistry: Serves as a practical example and tool in studying phthaloyl group introduction and removal strategies in advanced organic chemistry.

Basic Information

Product Name	Pth-L-Histidine Hydrochloride
CAS No.	65111-47-9
Molecular Formula	C₁₄H₁₅N₃O₄·HCl
Molecular Weight	325.75 g/mol
Synonyms	N-Phthaloyl-L-histidine hydrochloride; (S)-2-(1H-Imidazol-4-ylmethyl)-4-phthalimidobutanoic acid hydrochloride; PTH-His-OH·HCl; Phthalimidohistidine hydrochloride; L-Histidine, N-phthaloyl-, hydrochloride; Nα-Phthaloyl-L-histidine hydrochloride; N-Phthalyl-L-histidine hydrochloride
EINECS	Contact for details

Quality Control

Our Pth-L-Histidine Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing parameters such as assay, chiral purity, and impurity profiles. While typically supplied as a high-purity biochemical grade, production can be aligned with specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Specific range provided on COA
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.