Description

Phenylthiohydantoin-Aspartic Acid (CAS NO 5624-08-8) is a specialized derivative of aspartic acid, a fundamental amino acid, modified with a phenylthiohydantoin moiety. This compound is of significant value in advanced biochemical research and analytical chemistry, particularly in the field of protein sequencing and peptide analysis. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and manufacturers of diagnostic reagents who require high-purity, well-characterized biochemical intermediates for method development and quality control.

Application

• Protein Sequencing Reagent: A critical intermediate in the Edman degradation process for N-terminal amino acid analysis of peptides and proteins.
• Biochemical Research Standard: Used as a reference standard in analytical methods like HPLC and mass spectrometry for calibrating peptide sequencing workflows.
• Pharmaceutical Development: Serves as a building block or analytical marker in the research and development of peptide-based therapeutics.
• Diagnostic Kit Manufacturing: Employed in the production of high-sensitivity diagnostic kits for protein characterization and biomarker discovery.
• Academic Research: Utilized in university and institutional labs for studies in proteomics, enzymology, and molecular biology.
• Quality Control (QC) Applications: Acts as a known compound for verifying the performance and accuracy of amino acid analyzers and sequencers.

Basic Information

Product Name	Phenylthiohydantoin-Aspartic Acid
CAS No.	5624-08-8
Molecular Formula	C₁₃H₁₂N₂O₄S
Molecular Weight	292.31 g/mol
Synonyms	PTH-Aspartic Acid; PTH-Asp; 3-Phenyl-2-thiohydantoin-5-yl-propionic Acid; 5-(2-Carboxyethyl)-3-phenyl-2-thiohydantoin; Aspartic Acid Phenylthiohydantoin Derivative; Edman Degradation Product of Asp; (2S)-2-Amino-3-[[(phenylamino)thioxomethyl]amino]-3-oxopropanoic Acid (IUPAC); PTH-D-Asp (for D-isomer)
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin-Aspartic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent absorption of moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.