Description

Pth-Norvaline CAS NO 66703-27-3 is a protected amino acid derivative, specifically the phthaloyl (Pth) derivative of norvaline, which serves as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise control over peptide structure and function during multi-step synthetic sequences. It is primarily utilized in pharmaceutical research, peptide chemistry, and the development of novel bioactive compounds where the selective protection and deprotection of amino groups are paramount.

Application

• Pharmaceutical Intermediates: Key starting material or protected intermediate in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate norvaline while protecting the α-amino group from unwanted side reactions.
• Biochemical Research: Employed in studying enzyme-substrate interactions, metabolic pathways, and as a tool compound in proteomics research.
• Agrochemical Development: Serves as a precursor in the synthesis of specialized amino acid-based fungicides or plant growth regulators.
• Material Science: Potential monomer for creating novel polyamides or specialty polymers with tailored properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity, protected amino acids.

Basic Information

Product Name	Pth-Norvaline
CAS No.	66703-27-3
Molecular Formula	C₁₃H₁₃NO₄
Molecular Weight	247.25 g/mol
Synonyms	N-Phthaloylnorvaline; 2-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanoic acid]; Phthaloyl-DL-norvaline; DL-2-Phthalimidopentanoic acid; Norvaline, N-phthaloyl-; PTH-Nva; N-Phthalimido-n-valeric acid; 2-(1,3-Dioxoisoindolin-2-yl)pentanoic acid
EINECS	Contact for details

Quality Control

Our Pth-Norvaline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.