Description

2-Fluoro-4-Biphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in advanced organic synthesis. Its core value lies in its ability to act as a powerful nucleophile for the formation of carbon-carbon bonds, enabling the efficient construction of complex fluorinated biphenyl scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it serves as a critical building block for active pharmaceutical ingredients (APIs), liquid crystal materials, and functional organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated biphenyl derivatives used in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides with fluorinated aromatic cores.
• Liquid Crystal Materials: Serves as a precursor for fluorinated biphenyl compounds essential in display technology.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of fluorinated charge-transport or emissive materials.
• Cross-Coupling Reactions: A crucial reagent in Negishi, Kumada, and other transition metal-catalyzed cross-coupling reactions.
• Fine Chemical & Specialty Chemical Production: Used for introducing the 2-fluoro-4-biphenyl moiety into complex target molecules.
• Academic & R&D Laboratories: A valuable tool for methodological development and exploring new synthetic pathways in organometallic chemistry.

Basic Information

Item	Detail
Product Name	2-Fluoro-4-Biphenylmagnesium Bromide
CAS No.	76699-46-2
Molecular Formula	C12H8BrFMg
Molecular Weight	275.40 g/mol
Synonyms	2-Fluoro-4-phenylphenylmagnesium bromide; (2-Fluoro[1,1'-biphenyl]-4-yl)magnesium bromide; 4-Bromo-2'-fluorobiphenyl Grignard reagent; p-(2-Fluorophenyl)phenylmagnesium bromide; 2-Fluoro-4-biphenyl Grignard reagent; Magnesium, bromo(2-fluoro[1,1'-biphenyl]-4-yl)-; (4-Biphenylyl-2-fluoro)magnesium bromide
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Biphenylmagnesium Bromide is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including titration to determine active reagent concentration and assessment of solution quality. A Certificate of Analysis (COA) detailing specific results is provided with every shipment, confirming compliance with our rigorous internal specifications.

Storage

Preserve in a tightly closed container, protected from light. This compound is easily oxidized and must be stored under an inert atmosphere (argon or nitrogen). Due to its high volatility and reactivity, it should be kept in a cool, dry, well-ventilated area, away from moisture, heat, and incompatible materials such as strong acids and oxidizing agents. For optimal stability, storage at 2-8°C is recommended for extended periods.

Specification

Item	Specification
Appearance	Clear solution, typically brown to dark brown
Concentration (in THF or Ether)	0.5 M - 1.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR / NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.