Description

Glycerol-1,2,3-3H is a high-specific-activity, tritium-labeled derivative of glycerol, a fundamental biochemical building block. This labeled compound is essential for advanced research requiring precise metabolic and biochemical pathway tracing. It is a critical tool for scientists in pharmaceutical development, life sciences research, and analytical chemistry who require reliable, high-purity radiolabeled tracers for autoradiography, pharmacokinetic studies, and lipid metabolism research.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the biosynthesis and turnover of complex lipids, phospholipids, and triglycerides in vivo and in vitro.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the metabolic fate of drug candidates and their metabolites.
• Biochemical Research: Serves as a precursor in enzymatic assays and studies of glycerolipid and glycerophospholipid metabolism.
• Autoradiography & Imaging: Provides the radioactive signal for tissue and cellular imaging techniques to visualize lipid synthesis and localization.
• Quality Control & Reference Standard: Acts as an internal standard or reference material in analytical methods like Liquid Scintillation Counting (LSC) and HPLC for method validation.

Basic Information

Product Name	Glycerol-1,2,3-3H
CAS No.	76550-75-9
Molecular Formula	C3H53H3O3
Molecular Weight	95.09 g/mol (for 3H3 form)
Synonyms	[1,2,3-3H]Glycerol; Glycerol (tritiated); Glycerin-3H; 1,2,3-Tritioglycerol; Tritiated Glycerol; [3H]Glycerol; GT; Radiolabeled Glycerol
EINECS	Contact for details

Quality Control

Every batch of Glycerol-1,2,3-3H is manufactured and analyzed under strict quality systems to ensure high radiochemical purity and specific activity. Our products undergo rigorous quality testing, including analysis by HPLC with radiometric detection. Comprehensive Certificates of Analysis (COA) are provided, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. We adhere to GMP principles for the production of radiolabeled compounds for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as specified on the label and COA. Due to its highly volatile nature, ensure containers are securely sealed and handled in appropriate fume hoods or ventilated areas to minimize exposure and prevent loss of material. For long-term storage, keep in a dedicated, well-ventilated freezer.

Specification

Item	Specification
Appearance	Clear, colorless solution
Identification (HPLC)	Conforms
Specific Activity	10-50 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water (9:1) or as specified
Concentration	1 mCi/mL (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.