Description

Poly(2'-Methylthioadenylic Acid) is a synthetic polynucleotide analog derived from adenosine, where a methylthio group is substituted at the 2' position of the ribose sugar. This structural modification confers unique biochemical properties, making it a valuable tool for research in molecular biology and enzymology. It is primarily utilized by researchers in academic, pharmaceutical, and biotechnology laboratories for studying nucleic acid interactions, enzyme mechanisms, and as a potential precursor for specialized oligonucleotide synthesis.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for polymerases, nucleases, and methyltransferases.
• Nucleic Acid Chemistry: Serves as a building block or model compound for investigating the structure-activity relationships of modified nucleotides.
• Pharmaceutical R&D: Potential application in the development of nucleotide-based therapeutics or diagnostic probes targeting specific enzymatic pathways.
• Enzyme Mechanism Studies: Employed to probe the active sites and catalytic mechanisms of enzymes that process adenosine derivatives.

Basic Information

Product Name	Poly(2'-Methylthioadenylic Acid)
CAS No.	70804-88-5
Molecular Formula	(C11H14N5O6PS)n
Molecular Weight	375.30 (monomer)
Synonyms	Poly(2'-Methylthioadenosine 5'-monophosphate); Poly(2'-S-Methyladenylic Acid); 2'-Methylthio-poly(A); Poly(2'-MTA); Polynucleotide analog of 2'-methylthioadenosine; 2'-(Methylthio)adenosine homopolymer; Poly(2'-deoxy-2'-(methylthio)adenylic acid)
EINECS	Contact for details

Quality Control

Our Poly(2'-Methylthioadenylic Acid) is produced under controlled conditions to ensure batch-to-batch consistency for research applications. Each lot undergoes rigorous quality testing, including assessment of polymer length distribution and chemical identity. A Certificate of Analysis (COA) detailing specific parameters is available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 90% (Polymer Content)
Solubility	Soluble in aqueous buffers, DMSO
Chain Length (n)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.