Description

Mitoxantrone Hydrochloride is a synthetic anthracenedione derivative used as a potent antineoplastic agent. Its primary value lies in its ability to intercalate with DNA and inhibit topoisomerase II, leading to cytotoxic effects in rapidly dividing cells. This makes it a critical active pharmaceutical ingredient (API) for the formulation of injectable chemotherapy drugs, primarily targeting markets in pharmaceutical manufacturing and advanced research.

Application

• Oncological Pharmaceutical Manufacturing: As the active pharmaceutical ingredient (API) in injectable formulations for chemotherapy.
• Treatment of Specific Cancers: Used in drugs for treating acute myeloid leukemia (AML), advanced prostate cancer, and secondary progressive multiple sclerosis (MS).
• Biomedical Research: Serves as a key chemical tool in oncology research for studying DNA intercalation, apoptosis, and mechanisms of topoisomerase II inhibition.
• Reference Standard: Used in analytical laboratories as a high-purity standard for quality control (QC) and assay development of pharmaceutical products.
• Drug Discovery & Development: Employed in preclinical studies for evaluating new combination therapies and drug delivery systems.

Basic Information

Product Name	Mitoxantrone Hydrochloride
CAS No.	70476-82-3
Molecular Formula	C22H28N4O6 • 2HCl
Molecular Weight	517.41 g/mol (for free base: 444.49 g/mol)
Synonyms	Mitoxantrone Dihydrochloride; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione Dihydrochloride; Novantrone; DHAQ; CL 232315; NSC 301739; Mitozantrone Hydrochloride
EINECS	Contact for details

Quality Control

Our Mitoxantrone Hydrochloride is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition, referencing pharmacopeial monographs where applicable. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Blue-black solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.