Description

4-Chlorophenylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry. Its primary value lies in its ability to act as a powerful nucleophile for the formation of carbon-carbon bonds, enabling the synthesis of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing aryl-containing active pharmaceutical ingredients (APIs), including potential drug candidates for central nervous system and anti-inflammatory applications.
• Agrochemical Production: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the 4-chlorophenyl moiety imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in cross-coupling and other transition metal-catalyzed reactions.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with tailored electronic or optical properties.
• Fine Chemical Manufacturing: Integral to the production of dyes, pigments, and other high-value specialty chemicals requiring aryl group incorporation.
• Academic and R&D Laboratories: A fundamental reagent for methodological development and exploratory synthesis in organic chemistry research.

Basic Information

Item	Detail
Product Name	4-Chlorophenylmagnesium Bromide
CAS No.	73-77-8
Molecular Formula	C6H4ClMgBr
Molecular Weight	215.75 g/mol
Synonyms	(4-Chlorophenyl)magnesium bromide; p-Chlorophenylmagnesium bromide; 1-Chloro-4-(bromomagnesio)benzene; Grignard Reagent (p-ClC6H4MgBr); Magnesium, bromo(4-chlorophenyl)-; 4-Chlorophenyl Grignard Reagent; Bromo(4-chlorophenyl)magnesium
EINECS	Contact for details

Quality Control

Our 4-Chlorophenylmagnesium Bromide is produced under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Typical quality assessments include titration to determine the concentration of the Grignard reagent in solution and analysis of by-products. A Certificate of Analysis (COA) detailing purity, concentration, and solvent is provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive), this product must be stored under a dry, inert gas atmosphere (argon or nitrogen) in a cool, dry place. The solution is highly volatile and flammable; keep away from heat, sparks, and open flames. Store in a dedicated area for pyrophoric/organometallic reagents.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR / NMR)	Conforms to structure
Solvent	Typically Tetrahydrofuran (THF) or Diethyl Ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.