Description

Neopentylzinc Bromide is a highly reactive organozinc reagent, specifically a dialkylzinc compound, valued for its utility in advanced organic synthesis. Its primary commercial significance lies in its role as a versatile nucleophile for the efficient introduction of the neopentyl group, enabling the construction of complex, sterically hindered molecular architectures. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to synthesize novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating sterically demanding carbon frameworks in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of specialized pesticides and herbicides where the neopentyl moiety imparts stability and specific bioactivity.
• Cross-Coupling Reactions: Acts as a transmetalation agent in Negishi and related cross-coupling reactions to form new carbon-carbon bonds.
• Polymer & Material Science: Employed as an initiator or co-monomer in the development of specialized polymers and advanced organic materials.
• Fine Chemical Production: Facilitates the synthesis of complex natural product analogs, flavors, and fragrances.
• Academic & Industrial R&D: A critical reagent for methodological development in organometallic chemistry and new synthetic pathway exploration.

Basic Information

Product Name	Neopentylzinc Bromide
CAS No.	676137-12-5
Molecular Formula	C5H11BrZn
Molecular Weight	216.44 g/mol
Synonyms	Bromo(neopentyl)zinc; Zinc, bromo(2,2-dimethylpropyl)-; (2,2-Dimethylpropyl)zinc bromide; Neopentyl zinc bromide; (Neopentyl)ZnBr; Bromoneopentylzinc; (tert-Butylmethyl)zinc bromide
EINECS	Contact for details

Quality Control

Our Neopentylzinc Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Quality is verified through analytical techniques including NMR, titration, and GC analysis to confirm identity, purity, and concentration. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality management system supports compliance with cGMP and ISO standards for industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. Due to its properties as a highly volatile and easily oxidized compound, it must be handled in a dry, oxygen-free environment. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Concentration (Titration)	0.5 M in specified solvent (e.g., THF, Diethyl ether)
Purity (GC)	≥ 95% (organozinc content)
Solvent	As specified (Typical: Tetrahydrofuran)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.