Description

Cytidine 5'-Triphosphate Disodium is a high-purity nucleotide essential for RNA synthesis and other critical biochemical processes. This disodium salt form offers enhanced stability and solubility, making it a vital reagent for life science research and biopharmaceutical manufacturing. It is primarily utilized by researchers and process developers in molecular biology, enzymology, and the production of mRNA-based therapeutics and vaccines.

Application

• Substrate for RNA Polymerases: Essential nucleotide triphosphate (NTP) for in vitro transcription (IVT) reactions to synthesize mRNA, siRNA, and other RNA molecules.
• Biochemical Research: Used as a substrate or energy donor in enzymatic assays, studies of kinase activity, and metabolic pathway analysis.
• mRNA Vaccine & Therapeutic Production: A critical raw material in the manufacturing process for mRNA-based pharmaceuticals, requiring high purity and low endotoxin levels.
• PCR and cDNA Synthesis: Can be used in reverse transcription and related amplification techniques as a component of nucleotide mixes.
• Enzyme Cofactor Studies: Serves as a cofactor or regulator in studies involving ATP-dependent enzymes and other nucleoside triphosphate-utilizing proteins.
• Diagnostic Reagent Manufacturing: Incorporated into kits and reagents for molecular diagnostics and next-generation sequencing (NGS).

Basic Information

Product Name	Cytidine 5'-Triphosphate Disodium
CAS No.	652154-13-7
Molecular Formula	C9H14N3Na2O14P3
Molecular Weight	527.13 g/mol (anhydrous)
Synonyms	CTP Disodium Salt; Cytidine-5'-triphosphate disodium; 5'-CTP-Na2; Cytidine 5'-(tetrahydrogen triphosphate) disodium salt; Disodium cytidine 5'-triphosphate; CTP-Na2; Cytidine triphosphate disodium salt; 5'-CTP disodium
EINECS	Contact for details

Quality Control

Our Cytidine 5'-Triphosphate Disodium is manufactured under strict quality systems suitable for research and pharmaceutical applications. Each batch is tested to ensure high purity, identity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, purity by HPLC, identification, moisture content, endotoxin levels, and residual solvents where applicable. We support compliance with cGMP and ICH guidelines for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For extended storage under inert atmosphere, contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Anhydrous basis)
Purity (HPLC)	≥ 98.0% (Total nucleotide content)
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin (LAL)	< 10 EU/mg (for pharma grade)
Solubility	Freely soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.