Description

3'-o-tert-Butyldimethylsilyladenosine is a key protected nucleoside derivative, specifically an adenosine analog with a tert-butyldimethylsilyl (TBDMS) group at the 3'-hydroxyl position. This compound is essential for synthetic organic and medicinal chemists as a versatile building block in oligonucleotide synthesis, where it acts as a protective group for ribose hydroxyls, enabling precise, stepwise chain assembly. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing novel therapeutics, probes, and nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of DNA and RNA sequences in research and therapeutic development.
• Antiviral & Anticancer Prodrug Development: Serves as an intermediate in the synthesis of nucleoside analogs investigated for their antiviral and anticancer properties.
• Bioconjugation & Probe Design: Used to create labeled nucleotides for diagnostic assays, fluorescence in situ hybridization (FISH), and other molecular biology techniques.
• Medicinal Chemistry Research: Acts as a building block for modifying adenosine pathways and exploring new targets in purinergic signaling.
• Process Chemistry & Scale-up: Employed in the pilot and commercial-scale manufacturing of active pharmaceutical ingredients (APIs) for nucleic acid-based medicines.

Basic Information

Product Name	3'-o-tert-Butyldimethylsilyladenosine
CAS No.	69504-14-9
Molecular Formula	C17H29N5O4Si
Molecular Weight	395.53 g/mol
Synonyms	3'-O-(tert-Butyldimethylsilyl)adenosine; 3'-TBDMS-Adenosine; Adenosine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 3'-O-TBDMS-Ado; N6-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosine (protected form); 3'-O-(tert-Butyldimethylsilyl)-9-β-D-ribofuranosyladenine; TBDMS-Adenosine (3'-isomer)
EINECS	Contact for details

Quality Control

Every batch of 3'-o-tert-Butyldimethylsilyladenosine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting cGMP (current Good Manufacturing Practice) standards for advanced intermediates. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters are available upon request for quality assurance and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); containers must be kept sealed under inert atmosphere (argon or nitrogen) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.