Description

Bromo[10-[(Trimethylsilyl)Oxy]Decyl]Magnesium is a highly versatile organomagnesium reagent, specifically a Grignard reagent, valued for its unique bifunctional structure that combines a reactive carbon-magnesium bond with a protected terminal hydroxyl group. This compound is essential for introducing the 10-hydroxydecyl moiety into complex molecules, enabling precise carbon-carbon bond formation in advanced synthetic sequences. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing key intermediates and functionalized polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the construction of long-chain alkyl segments in active pharmaceutical ingredients (APIs), particularly in lipid-based drug conjugates and prodrugs.
• Agrochemical Manufacturing: Used to synthesize surfactants, adjuvants, and active compounds with specific hydrophobic chain lengths to enhance efficacy and environmental compatibility.
• Polymer & Material Science: Serves as a functional initiator or monomer in the production of specialty polymers, silicones, and surface-modifying agents where a protected hydroxyl group is required for subsequent reactions.
• Liquid Crystal & OLED Precursor: Employed in the synthesis of advanced organic electronic materials that require precisely defined alkyl spacers with terminal functionality.
• Cross-Coupling Reactions: Acts as a nucleophilic coupling partner in Kumada, Negishi, and related transition-metal catalyzed reactions to form complex carbon frameworks.
• Protecting Group Strategy: The trimethylsilyl (TMS) protected hydroxyl allows for orthogonal synthetic strategies, where the alcohol can be deprotected under mild conditions after the Grignard reaction is complete.

Basic Information

Product Name	Bromo[10-[(Trimethylsilyl)Oxy]Decyl]Magnesium
CAS No.	68516-34-7
Molecular Formula	C₁₃H₂₉BrMgOSi
Molecular Weight	333.67 g/mol
Synonyms	10-[(Trimethylsilyl)oxy]decylmagnesium bromide; (10-(Trimethylsilyloxy)decyl)magnesium bromide; Grignard Reagent (10-TMS-oxydecyl)MgBr; Magnesium, bromo[10-[(trimethylsilyl)oxy]decyl]-; 1-Bromo-10-((trimethylsilyl)oxy)decane magnesium derivative; TMS-Protected 10-Hydroxydecylmagnesium Bromide; 10-Hydroxydecylmagnesium bromide TMS ether
EINECS	Contact for details

Quality Control

Every batch of Bromo[10-[(Trimethylsilyl)Oxy]Decyl]Magnesium is manufactured and handled under strict inert atmosphere conditions to ensure reactivity and purity. Our quality assurance protocol includes rigorous analytical testing to confirm identity, concentration, and the absence of protic impurities that can deactivate the reagent. A comprehensive Certificate of Analysis (COA) detailing assay (by titration), solvent content, and functional group integrity is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). For optimal stability and to maintain reagent activity, store sealed under a dry, inert gas (argon or nitrogen) at recommended cold temperatures (typically 2-8°C). Allow the container to reach room temperature in a dry environment before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (as Grignard Reagent)	0.5 M in THF or as specified
Purity (Titration)	≥ 95%
Solvent (GC)	Specified anhydrous solvent (e.g., THF, Diethyl ether)
Water Content (KF)	< 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.