Description

Peplomycin is a bleomycin-derived glycopeptide antibiotic with potent antitumor activity, primarily functioning as a DNA strand scission agent. This compound is valued for its efficacy in research and development of novel chemotherapeutic agents and its role in studying DNA damage and repair mechanisms. It is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology and molecular biology.

Application

• Anticancer Research: A key reference standard and active component in studies investigating new chemotherapy drugs and combination therapies.
• Biochemical Research: Used as a tool compound to induce and study DNA damage, repair pathways, and apoptosis in cell cultures.
• Pharmaceutical Development: Serves as a starting material or intermediate in the synthesis and development of novel antitumor agents.
• Mechanistic Studies: Employed to understand the structure-activity relationship (SAR) of bleomycin analogues and their interaction with DNA.
• Quality Control: Used as a certified reference standard (CRS) for the assay and impurity profiling of bleomycin-related pharmaceuticals.

Basic Information

Product Name	Peplomycin
CAS No.	68247-85-8
Molecular Formula	C61H88N18O21S2
Molecular Weight	1449.6 g/mol
Synonyms	PEP; Peplomycin Sulfate; Pepleomycin; (S)-N1-[3-[(2-{[(2-{[(2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-Amino-2-carboxyethyl]carbamoyl}pyrrolidin-1-yl]carbonyl}pyrrolidin-1-yl]carbonyl}pyrrolidin-1-yl]carbonyl}pyrrolidin-1-yl)carbonyl]amino}ethyl)carbamoyl]ethyl]carbamoyl]propyl]bleomycinamide; NK 631; Pepreomycin; NK-631
EINECS	Contact for details

Quality Control

Our Peplomycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including identification, purity assay, and impurity profiling via advanced techniques like HPLC to ensure it meets high-purity standards suitable for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider conditions recommended for hygroscopic and light-sensitive pharmaceutical compounds.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.