Description

Deoxy-(Adenylyl-Thymidylyl-Adenylyl-Thymidylic Acid) is a defined-sequence oligonucleotide, specifically a tetrameric deoxyribonucleotide. This compound serves as a critical building block and reference standard in molecular biology and genetic research. It is essential for researchers and manufacturers in the fields of oligonucleotide synthesis, PCR primer development, and diagnostic probe design. Its defined sequence allows for precise study of nucleic acid interactions, hybridization kinetics, and enzymatic processes.

Application

• Research & Development: Used as a reference standard and model compound for studying DNA structure, stability, and hybridization properties.
• Oligonucleotide Synthesis: Serves as a key intermediate or building block in the solid-phase synthesis of longer, custom DNA sequences.
• Diagnostic Assays: Employed in the development and calibration of probes for genetic testing, fluorescence in situ hybridization (FISH), and other molecular diagnostic techniques.
• Biochemical Studies: Utilized as a substrate for investigating the activity and specificity of nucleases, ligases, polymerases, and other DNA-modifying enzymes.
• Pharmaceutical Research: Acts as a starting material or model for the development of antisense oligonucleotides and other therapeutic nucleic acid analogs.
• Quality Control: Functions as a system suitability test compound or calibration standard in analytical laboratories supporting biopharmaceutical manufacturing.

Basic Information

Product Name	Deoxy-(Adenylyl-Thymidylyl-Adenylyl-Thymidylic Acid)
CAS No.	68232-81-5
Molecular Formula	C39H48N15O23P3
Molecular Weight	1188.80 g/mol
Synonyms	d(ATAT); Deoxyadenylyl-thymidylyl-adenylyl-thymidylic Acid; dAdTdAdT; Oligodeoxyribonucleotide d(ATAT); ATAT Tetramer; DNA Tetramer (ATAT sequence); Thymidylyl-(3'→5')-deoxyadenylyl-(3'→5')-thymidylyl-(3'→5')-deoxyadenylic Acid
EINECS	Contact for details

Quality Control

Our oligonucleotide products are manufactured under strict quality-controlled conditions to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, mass spectrometry (MS), and UV spectrophotometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and concentration is provided with every shipment to support your research integrity and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation. For optimal performance, prepare working aliquots to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak matches theoretical mass
Purity (HPLC)	≥ 95% (254 nm)
Assay (UV)	≥ 85% (Anhydrous basis)
Water Content (KF)	≤ 5.0%
Extinction Coefficient (ε260)	~107,000 L·mol⁻¹·cm⁻¹

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.