Description

1-Methylpiperdin-4-Ylmagnesium Chloride, 0.50 M In Thf is a versatile organometallic reagent, specifically a Grignard reagent, supplied as a standardized solution in tetrahydrofuran (THF). This product is essential for introducing the 1-methylpiperidin-4-yl moiety in complex organic synthesis, enabling efficient carbon-carbon bond formation. It is a critical building block for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries seeking to develop novel active compounds and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing complex nitrogen-containing heterocycles and active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific piperidine-based architectures.
• Material Science Research: Employed in the creation of specialty polymers, ligands for catalysis, and organic electronic materials.
• Medicinal Chemistry & Drug Discovery: A valuable tool for parallel synthesis and library generation in lead optimization and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Serves as a nucleophile in stereoselective reactions to create chiral centers adjacent to nitrogen.
• Cross-Coupling Reactions: Can be used as a transmetalation agent in palladium-catalyzed cross-coupling reactions like Kumada coupling.

Basic Information

Product Name	1-Methylpiperdin-4-Ylmagnesium Chloride, 0.50 M In Thf
CAS No.	63463-36-5
Molecular Formula	C6H12ClMgN
Molecular Weight	157.92 g/mol (for C6H12ClMgN)
Synonyms	1-Methyl-4-piperidinylmagnesium chloride; 4-Magnesio-1-methylpiperidine chloride; (1-Methylpiperidin-4-yl)magnesium chloride; 1-Methyl-4-piperidylmagnesium chloride; 1-Methylpiperidine-4-magnesium chloride; N-Methyl-4-piperidylmagnesium chloride; Grignard Reagent from 1-Methyl-4-chloropiperidine
EINECS	Contact for details

Quality Control

Every batch of our 1-Methylpiperdin-4-Ylmagnesium Chloride solution is manufactured and tested under stringent quality control protocols to ensure consistency and reliability for your synthetic workflows. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing key parameters such as concentration, titration assay, and impurity profile. Our quality system is designed to meet the exacting standards required for cGMP and ISO-guided production environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dedicated, well-ventilated area for flammable materials. Due to its highly volatile and pyrophoric nature, the solution must be kept away from heat, sparks, open flames, and moisture. Use appropriate safety equipment and handling procedures for air-sensitive reagents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.50 M in THF
Assay (Titration)	0.45 - 0.55 M
Identification (IR)	Conforms to structure
Water Content (KF)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.