Description

3,5-Difluorophenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely utilized in synthetic organic chemistry for the formation of carbon-carbon bonds. Its primary value lies in its ability to introduce the 3,5-difluorophenyl moiety into complex molecular architectures, a key structural feature in advanced materials and active pharmaceutical ingredients (APIs). This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to synthesize novel fluorinated compounds.

Application

• Key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Building block for creating advanced agrochemicals, such as herbicides and fungicides, where fluorination enhances biological activity and environmental stability.
• Precursor in materials science for the development of liquid crystals, organic semiconductors, and polymers with tailored electronic and optical properties.
• Essential reagent in medicinal chemistry for structure-activity relationship (SAR) studies and the preparation of fluorinated analogs in drug discovery programs.
• Used in cross-coupling reactions and nucleophilic addition reactions to carbonyl compounds for constructing complex, fluorinated organic molecules.

Basic Information

Product Name	3,5-Difluorophenylmagnesium Bromide
CAS No.	62351-47-7
Molecular Formula	C6H3F2MgBr
Molecular Weight	217.30 g/mol
Synonyms	Magnesium, bromo(3,5-difluorophenyl)-; (3,5-Difluorophenyl)magnesium bromide; 3,5-Difluorophenylmagnesium bromide solution; 1,3-Difluoro-5-(bromomagnesio)benzene; Grignard Reagent 3,5-DifluorophenylMgBr; 3,5-Difluorophenyl MgBr; 3,5-Difluorobenzene, bromomagnesio-
EINECS	Contact for details

Quality Control

Our 3,5-Difluorophenylmagnesium Bromide is produced and handled under stringent quality management protocols. Each batch undergoes rigorous analytical testing, including titration for assay determination and GC analysis for solvent and impurity profiling, to ensure consistency and reliability for your synthetic workflows. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For solutions, store as recommended on the specific product label, typically at 2-8°C or under refrigeration. Keep away from heat, sparks, open flames, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light brown solution
Concentration (in THF or Ether)	Typically 0.5 M to 2.0 M
Assay (by Titration)	≥ 95% (of stated concentration)
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.