Description

2'-Amino-2'-Deoxyuridine-5'-Triphosphate is a modified nucleotide triphosphate analog, a critical building block for advanced molecular biology and biochemical research. Its primary value lies in its ability to incorporate into nucleic acid chains, serving as a vital tool for studying DNA/RNA structure, function, and enzymatic processes. This compound is essential for researchers and manufacturers in pharmaceutical development, molecular diagnostics, and life science research, particularly in applications requiring site-specific labeling or probing of nucleic acid interactions.

Application

• Enzymatic Synthesis of Modified Nucleic Acids: Used as a substrate for DNA/RNA polymerases to incorporate amino-modified bases into oligonucleotides.
• Probe and Primer Labeling: Enables the introduction of reactive amino groups for subsequent conjugation with fluorophores, biotin, or other reporter molecules.
• Structural and Mechanistic Studies: Facilitates research into polymerase fidelity, DNA repair mechanisms, and nucleic acid-protein interactions.
• Aptamer and SELEX Technology: Employed in the development of modified aptamers with enhanced stability or binding properties.
• Next-Generation Sequencing (NGS): Potential utility in specialized sequencing workflows and novel chemistry development.
• Cross-linking and Affinity Purification: The amino group provides a handle for creating cross-linked complexes or affinity tags.

Basic Information

Product Name	2'-Amino-2'-Deoxyuridine-5'-Triphosphate
CAS No.	61468-90-4
Molecular Formula	C9H15N3O14P3
Molecular Weight	506.15 g/mol
Synonyms	2'-Amino-2'-deoxy-UTP; Amino-dUTP; 2'-Amino-dUTP; 5'-Triphosphoric acid, 2'-amino-2'-deoxyuridine; 2'-Amino-2'-deoxyuridine triphosphate; dU(2'NH2)TP; 2'-NH2-dUTP; 2'-Amino-2'-deoxyuridine 5'-(tetrahydrogen triphosphate)
EINECS	Contact for details

Quality Control

Our 2'-Amino-2'-Deoxyuridine-5'-Triphosphate is manufactured under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability. We adhere to ISO 9001 quality management principles, and our production environment is designed to meet the exacting requirements of the life science industry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 90% (as triphosphate)
Solubility	Soluble in water, slightly soluble in methanol
pH (1% Solution)	6.0 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.