Description

Trimethylsilylethynylmagnesium Bromide is a highly reactive organomagnesium reagent, specifically a Grignard reagent, widely used in advanced organic synthesis. Its core value lies in its ability to efficiently introduce the versatile trimethylsilylethynyl group into molecular frameworks, enabling the construction of complex alkynes and serving as a key building block for pharmaceuticals and advanced materials. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise and reliable synthetic methodologies.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for constructing alkynyl-containing scaffolds found in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that incorporate acetylene functional groups.
• Material Science & Polymer Chemistry: Serves as a monomer or building block for creating conductive polymers, advanced resins, and specialty materials with tailored electronic properties.
• Organic Synthesis & Methodology Development: A fundamental tool in research laboratories for C-C bond formation, particularly in cross-coupling reactions and nucleophilic additions to carbonyl compounds.
• Liquid Crystal & OLED Material Production: Employed in the synthesis of organic semiconductors and light-emitting materials that require precise alkyne linkages.
• Natural Product & Fine Chemical Synthesis: Facilitates the introduction of acetylene units into complex natural product analogs and high-value fine chemicals.

Basic Information

Product Name	Trimethylsilylethynylmagnesium Bromide
CAS No.	61210-52-4
Molecular Formula	C5H11BrMgSi
Molecular Weight	203.44 g/mol
Synonyms	(Trimethylsilyl)ethynylmagnesium Bromide; Bromo(2-trimethylsilylethynyl)magnesium; (Trimethylsilylethynyl)magnesium Bromide; Ethynyltrimethylsilane, magnesium bromide derivative; TMS-acetylenylmagnesium Bromide; Grignard reagent TMS-C≡C-MgBr; Magnesium, bromo(2-trimethylsilylethynyl)-; (Trimethylsilyl)acetylene magnesium bromide complex
EINECS	Contact for details

Quality Control

Our Trimethylsilylethynylmagnesium Bromide is produced under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analysis, including titration for active Grignard concentration and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, concentration in solution (typically in THF or diethyl ether), and relevant impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This product is highly moisture-sensitive (hygroscopic) and must be stored under an inert atmosphere (argon or nitrogen) to prevent decomposition. For optimal stability, store the sealed reagent bottle at 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress. Use appropriate chemical storage cabinets with adequate ventilation.

Specification

Item	Specification
Appearance	Colorless to light yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (of Grignard reagent)
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.