Description

Phenylethynylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry for the formation of carbon-carbon bonds. Its primary value lies in its ability to introduce the phenylethynyl group into a diverse range of electrophiles, enabling the synthesis of complex alkynes and advanced pharmaceutical intermediates. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to build molecular complexity efficiently.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing alkynyl-containing active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and pesticides that incorporate acetylene functionalities.
• Material Science & Polymer Chemistry: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials requiring conjugated alkyne units.
• Cross-Coupling Reactions: Serves as a crucial reagent in Negishi, Kumada, and other transition-metal-catalyzed cross-coupling methodologies.
• Nucleophilic Addition Reactions: Reacts with carbonyl compounds (aldehydes, ketones, esters) to produce propargylic alcohols, which are versatile synthetic intermediates.
• Fine Chemical Synthesis: Facilitates the production of complex natural product analogs and specialty chemicals for research and industrial applications.

Basic Information

Product Name	Phenylethynylmagnesium Bromide
CAS No.	6738-06-3
Molecular Formula	C8H5BrMg
Molecular Weight	205.33 g/mol
Synonyms	Bromo(phenylethynyl)magnesium; Ethynylbenzene, bromomagnesium derivative; Magnesium, bromo(2-phenylethynyl)-; Phenylethynylmagnesium bromide solution; (Phenylethynyl)magnesium bromide; Grignard reagent, phenylethynylmagnesium bromide; Bromo(phenylethynyl)magnesium (1:1:1)
EINECS	Contact for details

Quality Control

Our Phenylethynylmagnesium Bromide is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as concentration (typically supplied as a solution in THF or diethyl ether), assay, and impurity profile. We adhere to cGMP principles where applicable, and our quality system is designed to meet the exacting standards of the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive and moisture-sensitive nature, this product must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. The container must be kept tightly sealed in a cool, dry, well-ventilated place, away from incompatible materials such as acids, oxidizers, and moisture.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms to structure
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.