Description

Netropsin Sulfate is a well-characterized, naturally occurring oligopeptide antibiotic with a high affinity for binding to the minor groove of double-stranded DNA at AT-rich sequences. This specific molecular interaction makes it a critical tool compound in biochemical and pharmacological research. It is primarily utilized by researchers and developers in the life sciences, pharmaceutical, and biotechnology sectors for studying nucleic acid structure, function, and as a model for designing novel therapeutic agents.

Application

• Biochemical Research: As a classic minor groove binder for studying DNA-protein interactions, chromatin structure, and gene regulation mechanisms.
• Pharmacological Studies: Serves as a reference compound and molecular scaffold in the development of new antiviral and anticancer agents targeting DNA.
• Molecular Biology: Used in assays to probe DNA conformation and to inhibit the activity of specific DNA-binding enzymes in vitro.
• Academic Research: A fundamental tool in university and institutional labs for fundamental research in biophysics, genetics, and medicinal chemistry.
• Pharmaceutical Development: Employed in early-stage drug discovery for target validation and as a comparator in screening programs for DNA-interactive compounds.

Basic Information

Product Name	Netropsin Sulfate
CAS No.	6018-79-7
Molecular Formula	C₁₈H₂₆N₁₀O₃ · H₂SO₄
Molecular Weight	542.55 g/mol
Synonyms	Netropsin; Congocidine; Sinanomycin; Antibiotic 5-113A; NSC 57153; 2-[2-(4-Amidino-1,2,3,4-tetrahydro-1-pyrimidyl)acetyl]-1-methyl-4,5,6,7-tetrahydro-1H-1,4-diazepine-4-carboxamidine sulfate; Pyrrolomycin
EINECS	Contact for details

Quality Control

Our Netropsin Sulfate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We support compliance with relevant research and development standards, and specifications can be provided to meet the rigorous demands of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.