Description

Methylmagnesium Chloride is a fundamental organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry. Its primary value lies in its ability to act as a powerful nucleophile and strong base, introducing methyl groups and forming new carbon-carbon bonds with high efficiency. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it serves as a critical building block for synthesizing complex molecules, active pharmaceutical ingredients (APIs), and specialty chemicals.

Application

Methylmagnesium Chloride is a versatile reagent with key applications across chemical synthesis:

• Pharmaceutical Intermediates: Crucial for the methylation of carbonyl compounds (ketones, aldehydes, esters) and epoxides in the synthesis of drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of pesticides, herbicides, and fungicides by constructing methyl-substituted aromatic and heterocyclic frameworks.
• Fine Chemical & Specialty Chemical Production: Employed in the manufacture of flavors, fragrances, dyes, and photoinitiators where precise methyl group introduction is required.
• Polymer & Material Science: Acts as an initiator or catalyst in certain polymerization reactions and in the surface modification of inorganic materials.
• Academic & Industrial R&D: A staple reagent in research laboratories for methodological development and exploratory synthesis of novel organic compounds.
• Deuterated Compound Synthesis: Used in conjunction with deuterated reagents for the preparation of methyl-deuterated compounds for analytical and research purposes.

Basic Information

Product Name	Methylmagnesium Chloride
CAS No.	676-58-4
Molecular Formula	CH3MgCl
Molecular Weight	74.79 g/mol
Synonyms	Chloromethylmagnesium; Magnesium, chloromethyl-; Methylmagnesium chloride solution; Grignard reagent, methylmagnesium chloride; Methyl magnesium chloride; Methylmagnesium chloride, 3.0 M in tetrahydrofuran; Methylmagnesium chloride, 1.0 M in diethyl ether; MCM
EINECS	211-625-5

Quality Control

Our Methylmagnesium Chloride is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as concentration (typically as a solution in THF or diethyl ether), assay, and impurity profiles. Our quality management system is designed to meet the exacting standards of GMP and ISO guidelines where applicable, supporting our commitment to supply chain integrity for critical B2B customers.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a highly volatile and moisture-sensitive organometallic compound, it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area, away from heat and ignition sources. For solutions, refer to the specific solvent's flammability and storage requirements. Keep the container tightly sealed when not in use to prevent concentration changes and degradation.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to slightly yellow liquid
Concentration (Typical)	1.0 M in Diethyl Ether or 3.0 M in Tetrahydrofuran
Assay (Titration)	≥ 95.0% (of stated concentration)
Identification (IR)	Conforms to standard
Water (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.