Description

11Beta,17-Dihydroxy-21-(4-Methyl-1-Piperazinyl)Pregna-1,4-Diene-3,20-Dione Monohydrochloride is a high-purity synthetic corticosteroid derivative, specifically a monohydrochloride salt form. This compound is valued for its potent anti-inflammatory and immunosuppressive pharmacological activity, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by research institutions and pharmaceutical manufacturers developing next-generation topical and systemic corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potent corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: Used in preclinical and clinical research to study glucocorticoid receptor activity, anti-inflammatory mechanisms, and metabolic pathways.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of corticosteroid drugs.
• Dermatological Formulations: A precursor in the development of advanced topical creams, ointments, and lotions for treating skin conditions like eczema, psoriasis, and dermatitis.
• Systemic Corticosteroid Production: Used in the manufacturing of injectable or oral corticosteroid medications for managing severe autoimmune and inflammatory disorders.

Basic Information

Product Name	11Beta,17-Dihydroxy-21-(4-Methyl-1-Piperazinyl)Pregna-1,4-Diene-3,20-Dione Monohydrochloride
CAS No.	60-39-9
Molecular Formula	C26H37ClN2O5
Molecular Weight	493.04 g/mol
Synonyms	Prednisolone 21-(4-Methylpiperazinyl) Monohydrochloride; 21-(4-Methyl-1-piperazinyl)pregna-1,4-diene-11β,17α-diol-3,20-dione Monohydrochloride; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(4-Methylpiperazine) Hydrochloride; U-67590A; NSC-106977; Prednisolone 21-(N-Methylpiperazinyl) Salt
EINECS	Contact for details

Quality Control

Our 11Beta,17-Dihydroxy-21-(4-Methyl-1-Piperazinyl)Pregna-1,4-Diene-3,20-Dione Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical R&D and intermediate use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.