Description

Prednisone 21-Acetate is a key pharmaceutical intermediate and synthetic corticosteroid derivative, widely recognized for its role in the production of potent anti-inflammatory and immunosuppressive medications. Its primary value lies in providing a versatile and reliable building block for the synthesis of advanced steroid-based APIs, ensuring high-purity input for critical drug manufacturing processes. This compound is essential for pharmaceutical R&D laboratories, fine chemical synthesis units, and manufacturers specializing in hormonal and steroidal therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) like prednisone and related corticosteroid drugs.
• Anti-inflammatory Drug Synthesis: Used in the manufacturing of medications designed to treat conditions such as arthritis, asthma, and autoimmune disorders.
• Immunosuppressant Production: Serves as a key starting material for drugs that modulate the immune system, used in organ transplantation and severe allergic reactions.
• Research & Development: Employed in biochemical and pharmacological research to study steroid metabolism, receptor binding, and the development of new therapeutic analogs.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC, GC, or spectroscopic assay calibration.
• Fine Chemical Synthesis: Acts as a specialized reagent in custom synthesis and process development for complex organic molecules within the steroid family.

Basic Information

Product Name	Prednisone 21-Acetate
CAS No.	125-10-0
Molecular Formula	C23H28O6
Molecular Weight	400.47 g/mol
Synonyms	21-Acetoxypregna-1,4-diene-3,11,20-trione; 1,4-Pregnadiene-3,11,20-trione, 21-(acetyloxy)-; Prednisone Acetate; NSC 527986; Cortisone 21-acetate derivative; 17α,21-Dihydroxypregna-1,4-diene-3,11,20-trione 21-acetate
EINECS	204-728-7

Quality Control

Our Prednisone 21-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical intermediate applications. We provide detailed Certificates of Analysis (COA) that include data for identity, purity, and related substances, aligning with industry expectations for fine chemicals. Specifications can be tailored to meet specific pharmacopeial requirements (e.g., USP/EP reference standards) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.