Description

Prednisolone Phosphate Sodium is a water-soluble prodrug of the potent glucocorticoid prednisolone, widely used in pharmaceutical formulations. Its primary value lies in its enhanced bioavailability and rapid conversion to the active metabolite, making it a critical intermediate for injectable and ophthalmic anti-inflammatory medications. This compound is essential for manufacturers in the pharmaceutical industry developing treatments for severe allergic reactions, ophthalmic inflammation, and other conditions requiring potent corticosteroid therapy.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in injectable corticosteroid formulations for systemic anti-inflammatory and immunosuppressive therapy.
• Ophthalmic Solutions: Key ingredient in eye drops and ophthalmic suspensions for treating inflammatory conditions of the eye, such as uveitis and allergic conjunctivitis.
• Veterinary Pharmaceuticals: Used in anti-inflammatory and immunosuppressive medications for companion and livestock animals.
• Research & Development: Serves as a critical reference standard and intermediate in pharmaceutical R&D for studying glucocorticoid receptor activity and developing new drug delivery systems.
• Hospital Compounding: Utilized in pharmacy compounding for preparing patient-specific sterile injectable preparations where commercial products are unsuitable.

Basic Information

Product Name	Prednisolone Phosphate Sodium
CAS No.	125-02-0
Molecular Formula	C21H27Na2O8P
Molecular Weight	484.38 g/mol
Synonyms	Prednisolone 21-Phosphate Disodium Salt; Sodium Prednisolone Phosphate; Disodium Prednisolone Phosphate; Prednisolone Sodium Phosphate; NSC-10039; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate) disodium salt; Solu-Prednisolone (trade name related); PPS
EINECS	204-728-6

Quality Control

Our Prednisolone Phosphate Sodium is manufactured under strict quality systems. We offer material compliant with major pharmacopoeial standards, including USP and EP monographs, ensuring it meets the rigorous requirements for pharmaceutical ingredient use. Every batch undergoes comprehensive analytical testing, including identity, purity, and impurity profile assays. A Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
pH (5% solution)	7.5 - 9.0
Specific Rotation	+97° to +103° (c=1 in water)
Bacterial Endotoxins	< 0.17 EU/mg (for injectable grade)
Sterility	Passes test (for sterile grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.