Description

16-Meprednisone Acetate is a synthetic corticosteroid derivative, specifically a methylated and acetylated analogue of prednisone. This compound is of significant interest in pharmaceutical research and development for its potent glucocorticoid activity. It serves as a critical intermediate and reference standard for the synthesis and analytical profiling of advanced steroid-based therapeutics. Key industries requiring this material include pharmaceutical R&D, contract manufacturing organizations (CMOs), and academic research institutions focused on endocrinology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel corticosteroid drugs and prodrugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) testing of steroid APIs and finished products via HPLC, GC, or LC-MS.
• Biochemical Research: Employed in preclinical studies to investigate structure-activity relationships (SAR) of glucocorticoid receptor agonists and antagonists.
• Metabolite Studies: Utilized as a standard in pharmacokinetic and metabolic stability studies to identify and quantify related steroid metabolites.
• Process Development: Serves as a model compound for optimizing fermentation, biocatalytic, or chemical synthesis routes for steroid manufacturing.

Basic Information

Product Name	16-Meprednisone Acetate
CAS No.	1106-03-2
Molecular Formula	C24H30O6
Molecular Weight	414.50 g/mol
Synonyms	16-Methylprednisone Acetate; 16-Methylprednisone 21-Acetate; 16β-Methylprednisone Acetate; 1,4-Pregnadiene-16β-methyl-11β,17α,21-triol-3,20-dione 21-acetate; 16β-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate; NSC 527986
EINECS	Contact for details

Quality Control

Our 16-Meprednisone Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.