Description

Betamethasone 21-Phosphate Disodium is a highly water-soluble phosphate ester salt of the potent glucocorticoid betamethasone. This form is critical for enabling parenteral administration, offering rapid anti-inflammatory and immunosuppressive action. It is an essential active pharmaceutical ingredient (API) for manufacturers of injectable corticosteroid formulations targeting severe allergic reactions, dermatological conditions, and inflammatory diseases.

Application

• Pharmaceutical API for injectable corticosteroid solutions and suspensions.
• Acute Anti-inflammatory Therapy for severe allergic reactions, asthma exacerbations, and anaphylaxis.
• Dermatological Treatments in formulations for severe eczema, psoriasis, and other inflammatory skin disorders.
• Rheumatology for managing acute flares of conditions like rheumatoid arthritis.
• Ophthalmic Solutions for treating severe inflammatory eye conditions.
• Veterinary Medicine in anti-inflammatory and immunosuppressive preparations for animals.
• Research & Development as a reference standard and for pharmacological studies on glucocorticoid receptor activity.

Basic Information

Product Name	Betamethasone 21-Phosphate Disodium
CAS No.	151-73-5
Molecular Formula	C22H28FNa2O8P
Molecular Weight	516.39 g/mol
Synonyms	Betamethasone Sodium Phosphate; Betamethasone 21-(Disodium Phosphate); 9α-Fluoro-16β-methylprednisolone 21-phosphate disodium salt; Flubenisolone 21-phosphate disodium salt; Celestone® Phosphate; Betnesol®; U-67590A; Betamethasone 21-Phosphate Disodium Salt
EINECS	205-796-5

Quality Control

Our Betamethasone 21-Phosphate Disodium is manufactured and tested under strict quality management systems. We ensure compliance with major pharmacopoeial standards, including USP and EP monographs. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, guaranteeing it meets the stringent requirements for pharmaceutical ingredient use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 8.0%
pH (5% solution)	7.5 - 9.0
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	< 1.0 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.