Description

Cortivazol is a synthetic corticosteroid derivative with potent anti-inflammatory and immunosuppressive properties. This compound is a critical intermediate in advanced pharmaceutical research and development, particularly for investigating novel glucocorticoid receptor modulators. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, well-characterized steroid intermediates. Cortivazol CAS NO 1110-40-3 is supplied under stringent quality control to ensure reliability for sensitive applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel corticosteroid-based therapeutics.
• Biomedical Research: Used as a reference standard and active agent in studies of glucocorticoid receptor (GR) activity, gene expression, and anti-inflammatory pathways.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemists to develop new anti-inflammatory and immunosuppressive drugs with improved efficacy and safety profiles.
• Mechanistic Studies: Employed in vitro and in vivo to investigate the molecular mechanisms of steroid action and cellular signaling.
• Analytical Standard: Used in HPLC, LC-MS, and other analytical methods for method development, validation, and quality control of related steroid products.

Basic Information

Product Name	Cortivazol
CAS No.	1110-40-3
Molecular Formula	C26H31FO6
Molecular Weight	458.52 g/mol
Synonyms	11β,17α,21-Trihydroxy-6,16α-dimethyl-2'-phenylpregna-2,4,6-trienol[3,2-c]pyrazol-20-one 21-acetate; 11β,17,21-Trihydroxy-6α,16α-dimethyl-2'-phenylpregna-1,4,6-trienol[3,2-c]pyrazol-20-one 21-acetate; Cortivazole; 2'-Phenylcortivazol; NSC-80998; L-5458
EINECS	Contact for details

Quality Control

Our Cortivazol is manufactured and tested to meet the exacting standards required for pharmaceutical research. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality management system ensures traceability and consistency, supporting compliance with cGMP and relevant ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.