Description

Prednisolone 21-Trimethylacetate is a key pharmaceutical intermediate and a protected ester derivative of the potent glucocorticoid prednisolone. This compound is crucial for enabling controlled synthesis and targeted delivery in advanced steroid-based therapies. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced corticosteroid drugs and prodrugs.
• Anti-inflammatory Drug Development: Used in research and manufacturing of medications for conditions like arthritis, asthma, and allergic reactions.
• Immunosuppressive Therapy: Serves as a precursor in the production of agents used to prevent organ transplant rejection and treat autoimmune diseases.
• Prodrug Synthesis: The trimethylacetate (pivalate) group acts as a protecting moiety, modifying solubility and bioavailability for improved drug delivery.
• Biochemical Research: Employed in laboratory studies to investigate glucocorticoid receptor activity and metabolic pathways.
• Veterinary Pharmaceuticals: Used in formulating anti-inflammatory treatments for animals.

Basic Information

Product Name	Prednisolone 21-Trimethylacetate
CAS No.	1107-99-9
Molecular Formula	C26H36O6
Molecular Weight	444.56 g/mol
Synonyms	Prednisolone Pivalate; Prednisolone 21-Pivalate; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-Pivalate; 21-(2,2-Dimethylpropanoyloxy)-11β,17α-dihydroxypregna-1,4-diene-3,20-dione; Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-11,17-dihydroxy-, (11β)-; NSC 52907
EINECS	214-170-6

Quality Control

Our Prednisolone 21-Trimethylacetate is manufactured under strict quality management systems. We offer material suitable for pharmaceutical research and development, with quality controls aligned with ICH guidelines. Every batch is tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residual Solvents (GC)	Complies with ICH limits
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.