Description

Dexamethasone-17-Acetate is a key pharmaceutical intermediate and a derivative of the potent glucocorticoid dexamethasone. This compound is essential for the synthesis and research of advanced corticosteroid-based medications, offering a critical building block for targeted therapeutic development. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in the production of anti-inflammatory, immunosuppressive, and oncological treatments.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for corticosteroid medications.
• Research & Development: Used in biochemical and pharmacological research to study glucocorticoid receptor activity and metabolic pathways.
• Anti-inflammatory Drug Synthesis: Serves as a starting material for developing potent topical and systemic anti-inflammatory agents.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory and immunosuppressive treatments for animals.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Oncology Research: Investigated for its potential role and derivatives in cancer treatment research protocols.

Basic Information

Product Name	Dexamethasone-17-Acetate
CAS No.	1177-87-3
Molecular Formula	C24H31FO6
Molecular Weight	434.50 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-acetate; Dexamethasone 21-Acetate (common misnomer); 17α,21-Dihydroxy-16α-methyl-9α-fluoro-1,4-pregnadiene-3,11,20-trione 21-acetate; DXM-17-Acetate; Dexamethasone Acetate (unspecified); NSC 39471; SQ 15102
EINECS	214-613-1

Quality Control

Our Dexamethasone-17-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with cGMP and relevant pharmacopeial guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.