Description

Hydrocortisone CAS NO 74050-20-7 is a vital corticosteroid hormone, also known as cortisol, which serves as a key active pharmaceutical ingredient (API). It is essential for its potent anti-inflammatory and immunosuppressive properties, making it a cornerstone in therapeutic formulations. This compound is primarily required by the pharmaceutical industry for the production of topical creams, ointments, injectables, and oral medications to treat conditions like adrenal insufficiency, allergies, and various inflammatory skin disorders.

Application

• Pharmaceutical API: Core ingredient in the manufacture of corticosteroid-based drugs for systemic and topical use.
• Topical Formulations: Used in creams, ointments, and lotions for treating eczema, psoriasis, dermatitis, and other inflammatory skin conditions.
• Injectable Solutions: Formulated for emergency treatment of adrenal crisis (Addisonian crisis) and severe allergic reactions.
• Ophthalmic Preparations: Key component in eye drops and ointments for treating ocular inflammation and allergies.
• Hormone Replacement Therapy: Used in medications for adrenal insufficiency to replace deficient natural cortisol.
• Veterinary Medicine: Employed in anti-inflammatory and immunosuppressive treatments for animals.
• Research & Development: Serves as a critical reference standard and biochemical tool in endocrine and pharmacological research.

Basic Information

Product Name	Hydrocortisone
CAS No.	74050-20-7
Molecular Formula	C21H30O5
Molecular Weight	362.46 g/mol
Synonyms	Cortisol; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione; 17-Hydroxycorticosterone; Compound F; Hydrocortisone base; Hydrocortisonum; NSC 10483; Hydrocort
EINECS	Contact for details

Quality Control

Our Hydrocortisone is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP, EP, and BP. Each batch undergoes rigorous analytical testing including identification, assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Specific Rotation	+150° to +156° (c=1 in ethanol)
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.