Description

4-Pregnene-20,21-Diol-3,11-Dione is a high-purity steroid intermediate of significant importance in pharmaceutical synthesis. This compound serves as a critical building block for the production of more complex corticosteroid and progestogen APIs, where consistent quality and reliable supply are paramount. It is primarily required by manufacturers in the pharmaceutical, biotechnology, and advanced fine chemical sectors for research and development as well as commercial production.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of corticosteroid drugs, including anti-inflammatory and immunosuppressive agents.
• Progestogen Synthesis: Used in the research and manufacturing pathways for various progestogen compounds.
• Biochemical Research: Serves as a reference standard and starting material in steroid metabolism and hormone action studies.
• Fine Chemical Production: Employed in the custom synthesis of specialized steroid derivatives for clinical and investigative applications.
• API Development: Integral to process development and scale-up activities for new Active Pharmaceutical Ingredients (APIs) within regulated environments.

Basic Information

Product Name	4-Pregnene-20,21-Diol-3,11-Dione
CAS No.	116-56-3
Molecular Formula	C21H30O4
Molecular Weight	346.46 g/mol
Synonyms	20,21-Dihydroxypregn-4-ene-3,11-dione; 20,21-Dihydroxy-4-pregnene-3,11-dione; 20,21-Dihydroxypregnenolone; 11-Oxo-20,21-dihydroxypregn-4-en-3-one; 20,21-Dihydroxy-11-oxopregn-4-en-3-one; 20,21-Dihydroxypregn-4-en-3,11-dione; Pregn-4-ene-20,21-diol-3,11-dione
EINECS	204-150-9

Quality Control

Our 4-Pregnene-20,21-Diol-3,11-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR), to ensure it meets exacting standards suitable for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.