Description

Hydrocortisone Sodium Succinate CAS NO 125-04-2 is the water-soluble sodium salt of hydrocortisone 21-hemisuccinate, a vital corticosteroid prodrug. This formulation is critical for enabling rapid intravenous or intramuscular administration, providing immediate anti-inflammatory and immunosuppressive effects. It is an essential active pharmaceutical ingredient (API) for manufacturers of injectable emergency medications, hospital solutions, and critical care formulations targeting severe allergic reactions, adrenal insufficiency, and inflammatory conditions.

Application

• Injectable Pharmaceutical Formulations: Primary use in sterile injectable solutions for rapid systemic corticosteroid delivery.
• Emergency & Critical Care Medicine: Key component in drugs for treating anaphylaxis, septic shock, and acute adrenal crisis (Addisonian crisis).
• Hospital Compounding: Used in hospital pharmacies for preparing IV infusions and IM injections.
• Anti-inflammatory & Immunosuppressive Therapy: Management of severe inflammatory conditions like rheumatoid arthritis flares, ulcerative colitis, and systemic lupus erythematosus.
• Oncology Supportive Care: Used to manage inflammation and side effects associated with certain chemotherapy regimens.
• Veterinary Pharmaceuticals: Employed in veterinary medicine for anti-inflammatory and shock therapy in animals.

Basic Information

Product Name	Hydrocortisone Sodium Succinate
CAS No.	125-04-2
Molecular Formula	C25H33NaO8
Molecular Weight	484.52 g/mol
Synonyms	Hydrocortisone 21-Hemisuccinate Sodium Salt; Cortisol Sodium Succinate; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(Sodium Succinate); Solu-Cortef (Pfizer brand name); EINECS 204-731-1; A-Hydrocort; Sodium Hydrocortisone Succinate
EINECS	204-731-1

Quality Control

Our Hydrocortisone Sodium Succinate is manufactured under strict quality systems suitable for pharmaceutical applications. We ensure compliance with relevant pharmacopoeial standards such as USP and EP monographs. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, confirming it meets stringent specifications for use in injectable drug products.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White or almost white, hygroscopic powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 5.0%
pH (5% Solution)	7.0 - 8.0
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Specific Rotation	+150° to +158° (c=1 in water)
Bacterial Endotoxins	< 0.17 EU/mg (for injectable grade)
Sterility	Conforms (for sterile grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.