Description

7-Deaza-7-Propargylamino-dATP is a chemically modified nucleotide analog designed for advanced molecular biology and diagnostic applications. This compound is critical for applications requiring high-fidelity nucleic acid labeling and detection, such as next-generation sequencing (NGS) probe synthesis. It is primarily utilized by research institutions, diagnostic kit manufacturers, and biotechnology companies specializing in genomics and molecular diagnostics.

Application

• Next-Generation Sequencing (NGS): Used in the synthesis of specialized probes and primers for targeted sequencing panels.
• Fluorescent In Situ Hybridization (FISH): Enables the incorporation of fluorescent labels into nucleic acid probes for cytogenetic analysis.
• Polymerase Chain Reaction (PCR): Serves as a modified substrate for PCR applications requiring labeled amplicons, including qPCR and digital PCR.
• DNA Microarray Fabrication: Employed in the production of high-density oligonucleotide arrays for gene expression profiling and genotyping.
• Diagnostic Assay Development: A key component in the manufacture of reagents for clinical diagnostic tests, including those for infectious diseases and genetic disorders.
• Chemical Biology Research: Used in click chemistry (CuAAC) applications for bioconjugation and tracking of nucleic acids.

Basic Information

Product Name	7-Deaza-7-Propargylamino-dATP
CAS No.	587848-72-4
Molecular Formula	C₁₅H₂₁N₆O₁₂P₃
Molecular Weight	618.32 g/mol
Synonyms	7-Deaza-7-propargylamino-2'-deoxyadenosine-5'-triphosphate; 7-Propargylamino-7-deaza-dATP; N⁶-(2-Propynyl)-7-deaza-2'-deoxyadenosine-5'-triphosphate; 7-Alkynylamino-7-deaza-dATP; Clickable dATP analog; Modified nucleotide triphosphate; Propargylamino-dATP; 7-Deaza-7-PA-dATP
EINECS	Contact for details

Quality Control

Our 7-Deaza-7-Propargylamino-dATP is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity, and impurity profiles. We support compliance with relevant standards for research and in vitro diagnostic (IVD) use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Suitable for enzymatic incorporation

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.