Description

3-(Trifluoromethoxy)Phenylmagnesium Bromide 0.5 In Thf is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the introduction of the 3-(trifluoromethoxy)phenyl moiety. This compound is valued for its ability to form new carbon-carbon bonds, enabling the construction of complex molecular architectures. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries, facilitating the development of novel active ingredients and specialty chemicals.

Application

• Key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethoxy-substituted aromatic ring.
• Building block for agrochemicals, such as herbicides and fungicides, where the trifluoromethoxy group enhances biological activity and stability.
• Precursor in material science for creating liquid crystals, organic semiconductors, and specialty polymers.
• Used in cross-coupling reactions (e.g., Kumada coupling) to synthesize biaryl compounds for various industrial applications.
• Employed in fine chemical synthesis for producing complex organic molecules in research and development laboratories.
• Facilitates the introduction of fluorinated groups into target molecules, a common strategy in modern drug design to improve metabolic stability and membrane permeability.

Basic Information

Product Name	3-(Trifluoromethoxy)Phenylmagnesium Bromide 0.5 In Thf
CAS No.	552332-04-4
Molecular Formula	C7H4BrF3OMg
Molecular Weight	265.31 g/mol (for C7H4BrF3OMg)
Synonyms	[3-(Trifluoromethoxy)phenyl]magnesium bromide; 3-(Trifluoromethoxy)phenylmagnesium bromide solution; 3-Trifluoromethoxyphenylmagnesium bromide; (3-Trifluoromethoxyphenyl)magnesium bromide; Magnesium, bromo[3-(trifluoromethoxy)phenyl]-; Grignard reagent 3-(Trifluoromethoxy)phenyl; 3-(Trifluoromethoxy)phenyl MgBr
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Phenylmagnesium Bromide 0.5 In Thf is produced and handled under stringent quality management systems. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC analysis of the THF solvent, to ensure consistency and reliability for your synthetic processes. Certificates of Analysis (COA) detailing purity, concentration, and solvent specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). Store under a dry, inert atmosphere (argon or nitrogen) at 2-8°C. The solution is flammable. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Concentration (in THF)	0.5 M (nominal)
Assay (by Titration)	0.45 - 0.55 M
Identification (IR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.