Description

2,4-Difluorobenzylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its value lies in introducing the versatile 2,4-difluorobenzyl group into molecular frameworks, a key structural motif for modulating the physical and biological properties of target compounds. This product is critically needed by R&D and process development chemists in the pharmaceutical, agrochemical, and advanced materials industries for constructing active pharmaceutical ingredients (APIs), crop protection agents, and specialty chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for the preparation of drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Active Ingredient Development: Used in the synthesis of novel herbicides, fungicides, and insecticides where the difluorobenzyl moiety enhances metabolic stability and bioavailability.
• Liquid Crystal & OLED Material Production: Serves as a precursor for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: Employed in Kumada, Negishi, and other transition-metal catalyzed couplings to create biaryl and complex aromatic structures.
• Nucleophilic Addition Reactions: Reacts with carbonyl compounds (aldehydes, ketones, esters) and epoxides to synthesize secondary and tertiary alcohols with fluorinated aromatic side chains.
• Custom Chemical & Contract Research Manufacturing: A critical reagent for fine chemical manufacturers and CROs/CMOs producing high-value, bespoke organic molecules for clients.

Basic Information

Product Name	2,4-Difluorobenzylmagnesium Bromide
CAS No.	546122-71-8
Molecular Formula	C7H5F2MgBr
Molecular Weight	223.32 g/mol
Synonyms	(2,4-Difluorophenyl)methylmagnesium Bromide; Magnesium, Bromo(2,4-difluorophenyl)methyl-; 2,4-Difluorobenzyl Magnesium Bromide; 2,4-Difluorobenzylmagnesium Bromide Solution; Grignard Reagent 2,4-Difluorobenzylmagnesium Bromide; (2,4-Difluorobenzyl)magnesium Bromide; α-Magnesiobromo-2,4-difluorotoluene
EINECS	Contact for details

Quality Control

Every batch of our 2,4-Difluorobenzylmagnesium Bromide is manufactured and tested under stringent quality systems. We provide comprehensive analytical data to ensure consistency and reliability for your critical synthesis steps. Certificates of Analysis (COA) detailing concentration (typically 0.5M to 2.0M in THF or other ethers), titration assay, and impurity profile are supplied with each shipment. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in its original sealed container. Recommended storage temperature is 2-8°C for extended stability. Keep away from heat, sparks, open flames, and strong oxidizers. Use only in a well-ventilated area with appropriate safety equipment.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow
Concentration	0.5M - 2.0M in THF (or specified solvent)
Assay (by Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.